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Methamphetamine (Desoxyn)

 
 

 

Chemistry

Chemical Name: DL-Methamphetamine
IUPAC NAME: N-Methyl-1-phenylpropan-2-amine
CAS No.: 7632-10-2
Molecular Formula: C10H15N
Molecular Weight: 149.23 g/mol
Density: 0.907 g/cm3 
Flash Point: 86.8 °C
Boiling Point: 215.5 °C at 760 mmHg
Following is the structure of Desoxyn (7632-10-2):
The chemical synonymous of Desoxyn (7632-10-2) are DL-Desoxyephedrine ; Benzeneethanamine, N,a-dimethyl- (9CI) ; dl-Methamphetamin ; Ephedrine, deoxy- ; N,a-Dimethylbenzeneethanamine ; N,a-Dimethylphenethylamine

 

History

In November 1943, Abbott Laboratories submitted a New Drug Application (NDA) to the Drug Division at the U.S. Food and Drug Administration (FDA) for Desoxyn. Abbott requested approval for narcolepsy, mild depression, postencephalitic parkinsonism, chronic alcoholism, cerebral arteriosclerosis, and hay fever. The NDA included review articles from academic journals, case histories from physicians, and a 3-page testimonial from a patient with narcolepsy. All these requests were accepted, and the drug was approved in December, 1944. All of these indication approvals were eventually removed. The only two approved marketing indications remaining for methamphetamine are for ADHD and the short-term management of exogenous obesity, although the drug is clinically established as effective in the treatment of narcolepsy.A sustained-release formulation of methamphetamine in the form of a plastic-matrix tablet, named the Desoxyn Gradumet, was introduced after the standard Desoxyn formulation was introduced. Abbott discontinued production of the Desoxyn Gradumet in the Fall of 1999, citing “manufacturing difficulties” as the reason for its discontinuation. The 5 milligram immediate release tablet is the only formulation presently available.In a joint sale for US$40 million, Abbott sold their rights to Desoxyn and Tranxene to Ovation Pharmaceuticals. Able Labs produced the first generic formulation of methamphetamine hydrochloride in 2004, until the company went out of business the following year.

 

Uses

 Desoxyn (7632-10-2) is considered to have significant abuse potential.It is considered to not have any greater risk of misuse and addiction than its close relative amphetamine, although methamphetamine causes a higher degree of euphoria, a lesser degree of adverse physical reactions, and a longer lasting duration of effects than amphetamine.

 

Toxicity Data With Reference

1.     orl-rat LDLo:70 mg/kg     AEPPAE    Naunyn-Schmiedebergs Archiv fuer Experimentelle Pathologie und Pharmakologie. 195 (1940),647.
2.     ipr-rat LDLo:32 mg/kg     AEPPAE    Naunyn-Schmiedebergs Archiv fuer Experimentelle Pathologie und Pharmakologie. 195 (1940),647.
3.     scu-rat LD50:30 mg/kg     AIPTAK    Archives Internationales de Pharmacodynamie et de Therapie. 159 (1966),442.
4.     orl-mus LD50:34 mg/kg     JPETAB    Journal of Pharmacology and Experimental Therapeutics. 131 (1961),115.
5.     ipr-mus LD50:15 mg/kg     CPBTAL    Chemical and Pharmaceutical Bulletin. 22 (1974),1459.
6.     scu-mus LD50:10 mg/kg     AEPPAE    Naunyn-Schmiedebergs Archiv fuer Experimentelle Pathologie und Pharmakologie. 241 (1961),182.
7.     ivn-mus LD50:10 mg/kg     27ZIAQ    Drug Dosages in Laboratory Animals-A Handbook C.D. Barnes andL.G. Eltherington,Berkeley, CA.: Univ. of California Press,1965
8.     scu-cat LDLo:50 mg/kg     27ZIAQ    Drug Dosages in Laboratory Animals-A Handbook C.D. Barnes andL.G. Eltherington,Berkeley, CA.: Univ. of California Press,1973,158.

 

Safety Profile

Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. A powerful central nervous system stimulant. When heated to decomposition it emits toxic fumes of NOx. See also BENZEDRINE.

 

Specification

 Desoxyn (7632-10-2) is a psychostimulant drug intended for medical usage in the treatment of Attention Deficit/Hyperactivity Disorder (ADHD),narcolepsy and for the short-term treatment of exogenous obesity.It is currently a Schedule II substance of the Controlled Substances Act in the United States. Drugs that are listed as Schedule II substances, such as methamphetamine, are drugs that are recognized to have a high risk for misuse, physical addiction, and/or psychological addiction, but they still have clinically accepted medical usage, Schedule II drugs are the most restricted of drugs with accepted medicinal use.and it is a potent central nervous system stimulant that acts as a substrate at the norepinephrine, dopamine (DA) and serotonin (5-HT) neurotransmitters, triggering an influx of these neurotransmitters from the cytosol into the trans-synaptic space via a process of ‘reverse transport’ by the monoamine reuptake transporter proteins (in which methamphetamine molecules are exchanged for endogenous monoamine substrate molecules). The compound also inhibits the reuptake of the transmitters into the pre-synaptic neuron by competing for uptake as substrates for the transporter, causing them to remain in the synaptic cleft longer. The resulting increased levels of dopamine and norepinephrine in these synapses affect neurochemical mechanisms responsible for regulating heart rate, body temperature, blood pressure, appetite, attention, mood and responses associated with alertness or alarm conditions. While amphetamine and methamphetamine have similar effects on dopamine and noradrenaline release, methamphetamine is a far more effective agonist of serotonin.


Methamphetamine is a member of the amphetamine class of drugs that are widely known for their central nervous system stimulation effects. These drugs are generally used to treat attention-deficit hyperactivity disorder (ADHD), and were once widely used as appetite suppressants. They are also useful in the treatment of narcolepsy, a disease that leaves patients prone to sudden attacks of deep sleep. Unfortunately, amphetamines are among the most abused of all prescription drugs. Methamphetamine ranks at top of the list for abused amphetamines, and current trends to use this drug as a free base (ice) are leading to new problems in combating the war on drugs. Side effects of the amphetamines include irregular heartbeat, chest pain, fever, difficulty in breathing, dizziness, and increased blood pressure.

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5 responses to “Buy Desoxyn”

  1. buypercocet says :

    Ive done searches both here on BL and on google and oddly I cant seem to find an answer to this.
    Does anyone have an approximate equivalent dosage between adderall and desoxyn?

    For instance, if one were to normally take 40mg of adderall IR, what would be a similar dosage for desoxyn?

    I know that desoxyn behaves differently from adderall in that there are far less PNS effects and a greater dopamine release, but if someone could provide an estimation of what an equivalent dose of desoxyn would be for about 40mg of adderall, that would be great. Thanks-DG

    EDIT: Also, I have heard mixed reports regarding the effectiveness of snorting desoxyn. Some have said that very little is absorbed when snorting desoxyn and so alot is wasted. Other people seem to swear by snorting the stuff. Anyone know for sure about this?

  2. buypercocet says :

    I was prescribed 20mg Desoxyn a day for around 2.5 years, and I was switched to it from 35mg of Dexedrine a day and still found the Desoxyn a bit stronger. 35mg of Dexedrine is equipotent to probably 40-45mg of Adderall, so that’s a rough number for you. It’s hard to make a direct comparison, though, because the feeling between the two (d,-amp vs. d,-methamp) is quite different.

    Edit: Some people I know like to snort Desoxyn and found it effective, although I only ever used it orally or IV (which, contrary to what you might hear, IS effective)

  3. buypercocet says :

    Desoxyn has the benefit of lasting a lot longer than other pharmaceutical amphetamines such as Adderall or Dexedrine, despite it only being available in 5mg instant-release tablets. I took 10mg (2x5mg) in the morning and the same dose in the afternoon, but my morning dose didn’t wear off for around 8 hours, so I wouldn’t even start to be coming down before I took my afternoon dose (I took my AM dose around 9AM and re-dosed around 3PM).

    To give some perspective, because it is different for everyone, here’s a list of the other amphetamines I’ve been prescribed, the dose, and how long it lasted.
    Desoxyn (d,-methamphetamine): 10mg (2x5mg tabs) 7-8 hours
    Dexedrine Spansules (d,-amphetamine ER): 15mg (1x15mg capsules) 6-8 hours
    Dexedrine IR (d,-amphetamine): 10mg (1x10mg tabs) 4-5 hours
    Adderall XR (racemic amphetamine ER): 20mg (1x20mg capsules) 9-10 hours
    Adderall IR (racemic amphetamine): 20mg (1x20mg tabs) 4-5 hours
    Ritalin (methylphenidate): 20mg (1x20mg tabs) 5 hours
    Ritalin LA (methylphenidate ER): 20mg (1x20mg tabs) 8-10 hours
    Concerta (methylphenidate ER): 54mg (1x54mg tabs) 10-12 hours

    Desoxyn can easily last “too long” if dosed too late in the day, and while it doesn’t give the same physical “tweaky” effects caused by racemic amphetamine, methylphenidate, and, to a degree, dextroamphetamine, it will still keep you up for a long while.

    Wow, sorry to ramble on so much. Hopefully this helped answer your questions, and if you have any more regarding Desoxyn or other ADD medications, feel free to ask and I should be able to help.

  4. buypercocet says :

    I was prescribed Desoxyn for roughly 2.5 years at a max of 30mg (2x tabs three times a day). I started at 5mg x3 times daily but at 10mg (vs. single dose of 5mg) I found it most effective for my symptoms. I was on the same dose of 30mg/daily for 2 years and I never needed to increase my dose; tolerance didn’t increase every 4 months or so like all other of the amphetamine/amphetamine-type medications. The following are questions to your answers from personal experience:

    Q: if one were to normally take 40mg of adderall IR, what would be a similar dosage for desoxyn?

    A: In my opinion roughly 20mg (10mg Adderall = 5mg Desoxyn). Although its sort of tough to answer that question, its like comparing Methylphenidate to amphetamines.

    Q: Also, I have heard mixed reports regarding the effectiveness of snorting desoxyn. Some have said that very little is absorbed when snorting desoxyn and so is alot wasted. Other people seem to swear by snorting the stuff. Anyone know for sure about this?

    A: I insufflated only on rare occasions because I didn’t want to increase tolerance. WHEN I DID though, 10mg WOULD GET ME HIGH! Very talkative, social, colors slightly brighter, very comfortable body warmth! Very mild physical side effects and not bad comedown. Once again though, I didn’t do it too much.

    I’d like to make my own PERSONAL chart like nleksan did (my dose of Adderall was just increased and feel very concentrated) All the meds I’ve been prescribed; my max dose prescribed, their length and MY opinion of equivalent dose of 10mg Desoxyn:

    Adderall IR (dextroamphetamine/amphetamine salts): 5mg / length: 5 hours (approx) / max dose prescribed: 60mg
    Adderall XR (extended release d/l amphetamine salts): can’t compare XR meds / length: 7 hours / max dose prescribed: 60mg
    Concerta (extended release methylphenidate): can’t compare XR meds / length: 8-9 hours / max dose prescribed: 60mg
    Desoxyn (d-methamphetamine) can’t compare XR meds / length: 7 hours / max dose prescribed: 60mg
    I was prescribed Desoxyn for roughly 2.5 years at a max of 30mg (2x tabs three times a day). I started at 5mg x3 times daily but at 10mg (vs. single dose of 5mg) I found it most effective for my symptoms. I was on the same dose of 30mg/daily for 2 years and I never needed to increase my dose; tolerance didn’t increase every 4 months or so like all other of the amphetamine/amphetamine-type medications. The following are questions to your answers from personal experience:

    Q: if one were to normally take 40mg of adderall IR, what would be a similar dosage for desoxyn?
    A: In my opinion roughly 20mg (10mg Adderall = 5mg Desoxyn). Although its sort of tough to answer that question, its like comparing Methylphenidate to amphetamines.

    Q: Also, I have heard mixed reports regarding the effectiveness of snorting desoxyn. Some have said that very little is absorbed when snorting desoxyn and so is alot wasted. Other people seem to swear by snorting the stuff. Anyone know for sure about this?
    A: I insufflated only on rare occasions because I didn’t want to increase tolerance. WHEN I DID though, 10mg WOULD GET ME HIGH! Very talkative, social, colors slightly brighter, very comfortable body warmth! Very mild physical side effects and not bad comedown. Once again though, I didn’t do it too much.

    I’d like to make my own PERSONAL chart like nleksan did (my dose of Adderall was just increased and feel very concentrated) All the meds I’ve been prescribed; my max dose prescribed, their length and MY opinion of equivalent dose of 10mg Desoxyn:

    Adderall IR (dextroamphetamine/amphetamine salts): 5mg / length: 5 hours (approx) / max dose prescribed: 60mg
    Adderall XR (extended release d/l amphetamine salts): can’t compare XR meds / length: 7 hours / max dose prescribed: 60mg
    Concerta (extended release methylphenidate): can’t compare XR meds / length: 8-9 hours / max dose prescribed: 60mg
    Desoxyn (d-methamphetamine): 10mg / length: 5 hours / max prescribed 30mg
    Dexedrine (dextroamphetamine): 10mg / length: 4 hours / max prescribed 45mg
    Dexedrine Spansule (dextroamphetamine extended release) can’t compare XR meds / length: 6 hours / max prescribed 45mg
    Focalin (dexmethylphenidate): 5mg / length: 4 hours / max dose prescribed: 20mg
    Ritalin (methylphenidate): 2.5mg / length: 2.5 hours / max dose prescribed: 45mg
    Ritalin SR (extended release methylphenidate): can’t compare XR meds / length: 5 hours / max prescribed: 60mg
    Vyvanse (lisdexamfetamine dimesylate): 70mg XR equivalent 30mg Adderall XR / length: 11 hours / max prescribed: 70mg

    the only ADD medication that I believe I haven’t been prescribed is Focalin XR (EDIT: and the methylphenidate patch) but that is my own personal opinion on equivalent dosages.

  5. buypercocet says :

    That’s similar to what i’d get without tolerance, tho with any tolerance (as i have now) it’s like this:

    Adderall IR 30mg: 2.5~3hrs (orally, rectally); 1.5~2hrs (intranasally)
    Vyvanse (lisdexamphetamine) 70mg: 3~5hrs (the last hour is crashing)

    Focalin IR 10mg: 1.5~2.5hrs (regardless of MOA)

    Unfortunately that’s all i’ve tried in the last 3.5yrs. Hope to try Desoxyn one day if it’s at all like the d-methamp i’ve consumed on and off.. i.e small doses are so effective there’s little need to re-dose so frequently and tolerance doesn’t hit you in the face like with d(l)-amp

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